Comparison of LH concentrations in the early and mid-luteal phase in IVF cycles after treatment with HMG alone or in association with the GnRH antagonist Cetrorelix.
Tavaniotou A, Albano C, Smitz J, Devroey P.
Centre for Reproductive Medicine, Dutch-Speaking Free University of Brussels, Brussels, Belgium.
Hum Reprod. 2001 Apr;16(4):663-7.
Abstract
Luteinizing hormone (LH) is mandatory for the maintenance of the corpus luteum. Ovarian stimulation for IVF has been associated with a defective luteal phase. The luteal phases of two groups of patients with normal menstrual cycles and no endocrinological cause of infertility were retrospectively analysed in IVF cycles. Thirty-one infertile patients stimulated with human menopausal gonadotrophins (HMG) for IVF to whom the gonadotrophin-releasing hormone (GnRH) antagonist Cetrorelix 0.25 mg was also administered to prevent the LH surge (group I) were compared with 31 infertile patients stimulated with HMG alone (group II). Despite differences in the stimulation outcome, luteal LH serum concentrations were similar in the two groups. LH values dropped from 2.3 +/- 1 IU/l on the day of human chorionic gonadotrophin (HCG) administration to 1.1 +/- 0.7 IU/l on day HCG +2 in group I (P < 0.0001) and from 5.1 +/- 3 to 1.2 +/- 1.7 IU/l (P < 0.0001) in group II. In the mid-luteal phase, LH concentrations were low in both groups. Our results suggest that suppressed LH concentrations in the early and mid-luteal phase may not be attributed solely to the GnRH-antagonist administration. Pituitary LH secretion may be inhibited by supraphysiological steroid serum concentrations via long-loop feedback and/or by the central action of the exogenously administered HCG via a short-loop mechanism.
Publications abstracts in peer reviewed journals
-
Cecal volvulus after twin gestation: laparoscopic approach
-
Comparison between different routes of progesterone administration as luteal phase support in infertility treatments
-
Comparison of LH concentrations in the early and mid-luteal phase in IVF cycles after treatment with HMG alone or in association with the GnRH antagonist Cetrorelix.
-
Effect of clomiphene citrate on follicular and luteal phase luteinizing hormone concentrations in in vitro fertilization cycles stimulated with gonadotropins and gonadotropin-releasing hormone antagonist.
-
Endometrial hormone receptors and proliferation index on the day of ovum pick-up in GnRH analogue/hMG stimulated cycles with embryo transfer. Comparison to natural cycles and relation to clinical pregnancies
-
Endometrial integrin expression in the early luteal phase in natural and stimulated cycles for in vitro fertilization.
-
GnRH antagonists and endometrial receptivity in oocyte recipients: a prospective randomized trial
-
Impact of ovarian stimulation on corpus luteum function and embryonic implantation
-
Low-dose human chorionic gonadotropin during the proliferative phase may adversely affect endometrial receptivity in oocyte recipients
-
Luteal hormonal profile of oocyte donors stimulated with a GnRH antagonist compared with natural cycles
-
Ovulation induction disrupts luteal phase function.
-
The impact of LH serum concentration on the clinical outcome of IVF cycles in patients receiving two regimens of clomiphene citrate / gonadotrophin / 0.25 mg cetrorelix